Ndoile, Monicavan Heerden, Fanie2018-09-102018-09-102013http://hdl.handle.net/20.500.11810/4869The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental conditions for the oxidative cyclization to form ochnaflavone were established.biflavonediaryl ethernatural productsnucleophilic aromatic substitutionochnaflavonetetrahydroochnaflavoneJournal Article, Peer Reviewed