Marandu, Thomas F.Oduro, Jennifer D.Borkner, LisaDekhtiarenko, IrynaUhrlaub, JenniferDrabig, AnjaKröger, AndreaZugich, Janko N.Sain, Luka C.2016-07-082016-07-082015-09Marandu, T.F., Oduro, J.D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J.L., Drabig, A., Kröger, A., Nikolich-Zugich, J. and Cicin-Sain, L., 2015. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of virology, 89(22), pp.11715-11717.http://hdl.handle.net/20.500.11810/2837Latent herpesvirus infections alter the immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse CMV, HSV-1 and/or MHV-68 with Influenza, WNV or VSV. We observed no increase in mortality or weight-loss over herpesvirus-negative counterparts and a relative, but no absolute reduction in CD8 responses against acute infections. Therefore, herpesviruses do not appear to increase susceptibility to emerging infections in aging. Copyright © 2015, American Society for Microbiology. All Rights ReservedenImmune ProtectionLatent HerpesviralJournal Article, Peer Reviewed10.1128/JVI.01989-15 · Source: PubMed